It has a high reproductive rate and low incidence of spontaneous tumors. 22, No. "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Cephalalgia. In male rats, which are commonly used for permeability estimation, there were differences for Metoprolol permeability between Sprague-Dawley (with lower permeability values) and the other strains, while for Verapamil Sprague-Dawley and Wistar-Han showed the lower permeability values. 2017 Dec; 37(14):1350-1372. Like the Wistar rats, only about half of the rats consuming this diet for 3–5 months gained excess weight compared to chow-fed controls ( 20 , 24 – 26 ). MeSH (Medical Subject Headings). Am J Physiol Gastrointest Liver Physiol. Contact Us Below are the most recent publications written about "Rats, Sprague-Dawley" by people in Profiles. In rats, this is accomplished through inbreeding. studied the development of the hair follicle in individuals that displayed the hairless phenotype. Public Health Service . PLoS One. Taconic’s proven process ensures timed-pregnant rats bear litters within a 24-hour window of your desired gestational age. This breed of rat was first produced by the Sprague Dawley farms (later to become the Sprague … The CaMKII K42M and K42R mutations are equivalent in suppressing kinase activity and targeting. of Colorado, a body corporate. Am J Respir Crit Care Med. Sprague Dawley rats were first bred by the Sprague Dawley farm in Madison, Wisconsin in 1925 through multiple crosses with a single-hooded male and six albino female rats. 2020 04; 71(4):1378-1389.e3. Interestingly, the Sprague-Dawley rats had the highest percentage (87%) to develop thermal allodynia following contusion SCI, while 100% of both Long-Evans and Sprague Dawley rats developed thermal allodynia in the hemisection model. “Hairless” rats have hair shafts shaped like a lance head (“lanceolate”). NIH began a closed colony with animals obtained from Sprague Dawley, Inc. Hilltop Lab Animals, Inc. received animals from NIH in 1984. MeSH (Medical Subject Headings). Sprague Dawley Rat High Fat T Increases Pain Behaviors In Rats With Or Without Significance of malondialdehyde superoxide diase and tary factors in fasting blood glucose levels and weight gain charles river 2019 research models services us rnu rat charles river parison of two protocols carbon tetrachloride induced A strain, in reference to rodents, is a group in which all members are, as nearly as possible, genetically identical. Diethylstilbestrol (DES) at 15 microg/kg/day was used as a reference chemical with known estrogenic effects. Sprague Dawley rat: The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical and nutritional research. BJU Int. Hence, this study aimed to investigate the anti-obesity activity of Elateriospermum tapos (E. tapos) shell extract in obesity induced Sprague Dawley rats. Br J Anaesth. Descriptors are arranged in a hierarchical structure, SAS Sprague Dawley Rat … *indicates the intervals where L/M ratios of Fischer and Sprague-Dawley rats were significantly lower than the DI control. Mechanistic Target of Rapamycin Regulates the Oligodendrocyte Cytoskeleton during Myelination. This model has been tested and validated for use in oncology (SRG OncoRat®). 2017 Dec; 18(1):16. Sprague Dawley ® model makes it a preferred choice for generating timed-pregnant females. The Sprague Dawley (SD) rat is often used as a general multipurpose rat model, including safety and efficacy testing, aging, nutrition, diet-induced obesity, oncology, and for surgical procedures. Fong LY, Jing R, Smalley KJ, Wang ZX, Taccioli C, Fan S, Chen H, Alder H, Huebner K, Farber JL, Fiehn O, Croce CM. rhIGF-1/BP3 Preserves Lung Growth and Prevents Pulmonary Hypertension in Experimental Bronchopulmonary Dysplasia. 2018 04 02; 28(7):1079-1089.e4. A : Relative retroperitoneal fat weight. Supplementation with pumpkin seed oil improves plasma lipid profile and cardiovascular outcomes of female non-ovariectomized and ovariectomized Sprague-Dawley rats 20 June 2008 | Phytotherapy Research, Vol. CD® (Sprague Dawley) IGS Rat Details Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. The SPRAGUE DAWLEY® rat aka SD, is an albino outbred rat with … National Toxicology Program . (Harvard PROFILES RNS software version: 2.11.1). B01.050.150.900.649.313.992.635.505.700.750. Below are MeSH descriptors whose meaning is related to "Rats, Sprague-Dawley". Proc Natl Acad Sci U S A. 2020; 53(8):e9950. Vascular lesions in the blood vessels of Sprague-Dawley and Wistar rats include medial degeneration and medial hypertrophy. In the infamous study where the genetic predisposition for cancer was called out, researchers were using the Sprague-Dawley strain of laboratory rat. Authors Ying Piao 1 , Yunen Liu, Xiaodong Xie. Gibco Primary Rat Cortex Neurons, Sprague Dawley, are isolated and cryopreserved from Sprague Dawley embryonic day-18 rats. 2020 04; 145(4):949-956. Eisner V, Cupo RR, Gao E, Csordás G, Slovinsky WS, Paillard M, Cheng L, Ibetti J, Chen SR, Chuprun JK, Hoek JB, Koch WJ, Hajnóczky G. Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity. Braz J Med Biol Res. These neurons consistently yield post-thaw viability in the ran Descriptors are arranged in a hierarchical structure, A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. Sprague Dawley rats in health. J Invest Dermatol. 2020 04 08; 40(15):2993-3007. By having this kind of population, it is possible to conduct experiments on the roles of genes, or conduct experiments that exclude variations in genetics as a factor. SD rats are docile and are easy to handle. 2017 01 31; 114(5):E859-E868. Am J Physiol Gastrointest Liver Physiol. Below are MeSH descriptors whose meaning is more specific than "Rats, Sprague-Dawley". Male Sprague–Dawley (SD) rats (weighing 220–250 g) (Slac Laboratory Animal Corp., Shanghai) were kept under a 12-h day-night cycle at 20°C and a relative humidity of 50% for 7 days. Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty. Seedorf G, Kim C, Wallace B, Mandell EW, Nowlin T, Shepherd D, Abman SH. Tullis JE, Rumian NL, Brown CN, Bayer KU. which enables searching at various levels of specificity. The Ns for Fischer rats for (DI) water or 0.416, 0.5, 0.75, 1, 2, 5 or 10 mg/kg of ketanserin, respectively, were 5, 8, 9, 6, 10, 5, 13 and 7. Below are the most recent publications written about "Rats, Sprague-Dawley" by people in Profiles. Consortium, The Regents of the University Epub 2013 Apr 22. Cason CA, Kuntz TM, Chen EB, Wun K, Nooromid MJ, Xiong L, Gottel NR, Harris KG, Morton TC, Avram MJ, Chang EB, Gilbert JA, Ho KJ. The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical research. By contrast, outbred populations are used when identical genotypesare unnecessary or a population with genetic variation is required, and these rats are usually referred to as stocks rather than … The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical research. 7 It was developed by the Sprague-Dawley Animal Company. Below are MeSH descriptors whose meaning is more specific than "Rats, Sprague-Dawley". Sprague Dawley (Hsd:Sprague Dawley ® SD ®) Rats Exposed to Whole-body Radio Frequency Radiation at a Frequency (900 Mhz) and Modulations (GSM and CDMA) Used by Cell Phones Technical Report 595 . The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Hirsch K, Taglauer E, Seedorf G, Callahan C, Mandell E, White CW, Kourembanas S, Abman SH. A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. To CRL in 1950 from Sprague Dawley, Inc. Caesarean rederived in 1955 from original Charles River Sprague Dawley. Curr Biol. Juskeviciute E, Dippold RP, Antony AN, Swarup A, Vadigepalli R, Hoek JB. Perinatal Hypoxia-Inducible Factor Stabilization Preserves Lung Alveolar and Vascular Growth in Experimental Bronchopulmonary Dysplasia. 2017 Jan 01; 58(1):168-178. Proc Natl Acad Sci U S A. So yes, some laboratory rats … The breeding facilities were purchased first by Gibco and then by Harlan (now Harlan … We have created the immunodeficient SRG rat, a S prague-Dawley Rag2/Il2rg double knockout that lacks mature B cells, T cells, and circulating NK cells. 2020 06; 125(6):911-919. 2020 10 15; 202(8):1146-1158. Nascimento GC, de Paula BB, Lowry CA, Leite-Panissi CRA. People who have written about this concept. Sci Rep. 2020 01 24; 10(1):1136. Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites. 2017 May; 137(5):1025-1032. Diffusion Magnetic Resonance Imaging Predicts Peripheral Nerve Recovery in a Rat Sciatic Nerve Injury Model. Change trends of organ weight background data in sprague dawley rats at different ages J Toxicol Pathol. Ns for Sprague-Dawley rats, respectively, were 5, 8, 10, 6, 9, 5, 14 and 6. If you have any questions or feedback please contact us. "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, J Neurosci. Farinas AF, Manzanera Esteve IV, Pollins AC, Cardwell NL, Kaoutzanis C, Nussenbaum ME, Does MD, Dortch RD, Perdikis G, Thayer WP. In 1991, 8 colonies were selected to form the IGS Foundation Colony. 2020 05 01; 201(9):1120-1134. "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, Maintained by IS&T - Information Services & TechnologyCopyright© Thomas Jefferson University. Inhibition of miR-21 rescues liver regeneration after partial hepatectomy in ethanol-fed rats. Bhagwani AR, Farkas D, Harmon B, Authelet KJ, Cool CD, Kolb M, Goncharova E, Yoder MC, Clauss M, Freishtat R, Farkas L. Clonally selected primitive endothelial cells promote occlusive pulmonary arteriopathy and severe pulmonary hypertension in rats exposed to chronic hypoxia. Methods: An automated haematology analyzer was used to determine haematological indices of whole blood from individual in 20 each of male and female inbred Sprague Dawley rats. The strain was created by R. W. Dawley in 1925, from a hooded male hybrid of unknown origin and an albino female (probably Wistar), and was crossed with the female’s progeny for 7 generations. Below are MeSH descriptors whose meaning is more general than "Rats, Sprague-Dawley". Musah AS, Brown TL, Jeffries MA, Shang Q, Hashimoto H, Evangelou AV, Kowalski A, Batish M, Macklin WB, Wood TL. Temporomandibular inflammation mobilizes parvalbumin and FosB/deltaFosB neurons of amygdala and dorsal raphe. To see the data from this visualization as text. Tesic V, Joksimovic SM, Quillinan N, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABAA currents, but are not neurotoxic to the developing rat brain. B01.050.150.900.649.313.992.635.505.700.750. A flexible, ready-to-use, and quality alternative to fresh neurons, each vial contains one million cells per mL. SD rats are often referred to as "Sprague-Dawley®" Mr. Dawley used both his name and the maiden name, "Sprague", of his wife to create the name of the stock. 8, 10, 6, 9, 5, 8 colonies were selected form. 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